Journal of Medicinal Chemistry
Volume 43, Issue 13 (June 29, 2000)
Copyright © 2000 American Chemical Society

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COMMUNICATIONS

2489-2492

Reporter Affinity Labels: An o-Phthalaldehyde Derivative of -Naltrexamine as a Fluorogenic Ligand for Opioid Receptors Bertrand Le Bourdonnec, Rachid El Kouhen, Mary M. Lunzer, Ping Y. Law, Horace H. Loh, and Philip S. Portoghese [Full Article - PDF]

ARTICLES

2493-2505

A Three-Dimensional Model of Lanosterol 14-Demethylase of Candida albicans and Its Interaction with Azole Antifungals Haitao Ji, Wannian Zhang, Youjun Zhou, Min Zhang, Jie Zhu, Yunlong Song, Jiaguo Lü, and Jü Zhu [Full Article - PDF]

2506-2513

Docking-Based Development of Purine-like Inhibitors of Cyclin-Dependent Kinase-2 Michal Otyepka, Vladimír Krytof, Libor Havlíek, Vra Siglerová, Miroslav Strnad, and Jaroslav Koa [Full Article - PDF]

2514-2522

6-Acyloxy(nor)tropanes: Affinities for Antagonist/Agonist Binding Sites on Transfected and Native Muscarinic Receptors John W. Daly, Tara H. Gupta, William L. Padgett, and Xue-Feng Pei [Full Article - PDF]

2523-2529

4-(3-Chloro-4-methoxybenzyl)aminophthalazines: Synthesis and Inhibitory Activity toward Phosphodiesterase 5 Nobuhisa Watanabe, Hideyuki Adachi, Yasutaka Takase, Hirofumi Ozaki, Masayuki Matsukura, Kazuki Miyazaki, Keiji Ishibashi, Hiroki Ishihara, Kohtarou Kodama, Mayu Nishino, Motoharu Kakiki, and Yasuhiro Kabasawa [Full Article - PDF]

2530-2537

A Novel Approach for a Water-Soluble Long-Acting Insulin Prodrug: Design, Preparation, and Analysis of [(2-Sulfo)-9-fluorenylmethoxycarbonyl]3-insulin Eytan Gershonov, Itzhak Goldwaser, Mati Fridkin, and Yoram Shechter [Full Article - PDF]

2538-2546

Structure-Activity Relationships of (E)-5-(2-Bromovinyl)uracil and Related Pyrimidine Nucleosides as Antiviral Agents for Herpes Viruses Yongseok Choi, Ling Li, Sue Grill, Elizabeth Gullen, Chang Soo Lee, Giuseppe Gumina, Eisaku Tsujii, Yung-Chi Cheng, and Chung K. Chu [Full Article - PDF]

2547-2556

Aureobasidins: Structure-Activity Relationships for the Inhibition of the Human MDR1 P-Glycoprotein ABC-Transporter Françoise Tiberghien, Toru Kurome, Kazutoh Takesako, Agnès Didier, Tom Wenandy, and Francis Loor [Full Article - PDF]

2557-2565

Synthesis and Immunosuppressive Activity of Novel Prodigiosin Derivatives Roberto D'Alessio, Alberto Bargiotti, Orlando Carlini, Francesco Colotta, Mario Ferrari, Paola Gnocchi, Annamaria Isetta, Nicola Mongelli, Pietro Motta, Arsenia Rossi, Mario Rossi, Marcello Tibolla, and Ermes Vanotti [Full Article - PDF]

2566-2574

Synthesis and Cytokine Modulation Properties of Pyrrolo[2,3-d]-4-pyrimidone Nucleosides Guangyi Wang, Robert C. Tam, Esmir Gunic, Jinfa Du, Josie Bard, and Bharati Pai [Full Article - PDF]

2575-2585

QSAR Model for Drug Human Oral Bioavailability Fumitaka Yoshida and John G. Topliss [Full Article - PDF]

2586-2590

Enkephalin Glycopeptide Analogues Produce Analgesia with Reduced Dependence Liability Edward J. Bilsky, Richard D. Egleton, Scott A. Mitchell, Michael M. Palian, Peg Davis, Jason D. Huber, Heather Jones, Henry I. Yamamura, Jacqueline Janders, Thomas P. Davis, Frank Porreca, Victor J. Hruby, and Robin Polt [Full Article - PDF]

2591-2600

Poly(N-acryl amino acids): A New Class of Biologically Active Polyanions Alfonso Bentolila, Israel Vlodavsky, Rivka Ishai-Michaeli, Olga Kovalchuk, Christine Haloun, and Abraham J. Domb [Full Article - PDF]

BRIEF ARTICLES

2601-2607

Novel Nonsubstrate Inhibitors of Human Thymidine Phosphorylase, a Potential Target for Tumor-Dependent Angiogenesis Federico Focher, Daniela Ubiali, Massimo Pregnolato, Chengxin Zhi, Joseph Gambino, George E. Wright, and Silvio Spadari [Full Article - PDF]

BOOK REVIEWS

2608-2608

Writing Reaction Mechanisms in Organic Chemistry, Second Edition By Audrey Miller and Philippa H. Solomon. Harcourt Academic Press, New York. 2000. xiv + 471 pp. 19 x 23.5 cm. ISBN 0-12- 496712-4. $48.50. Patrick M. Woster [Full Article - PDF]

2608-2608

The Organic Chemistry of Enzyme-Catalyzed Reactions By Richard B. Silverman. Academic Press, San Diego, CA. 2000. xvii + 717 pp. ISBN 0-12-643745-9. $89.95. D. Eric Walters [Full Article - PDF]