COMMUNICATIONS
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2489-2492
Reporter Affinity Labels: An o-Phthalaldehyde Derivative of -Naltrexamine as a Fluorogenic Ligand for Opioid Receptors
Bertrand Le Bourdonnec,
Rachid El Kouhen,
Mary M. Lunzer,
Ping Y. Law,
Horace H. Loh, and
Philip S. Portoghese
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ARTICLES
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2493-2505
A Three-Dimensional Model of Lanosterol 14-Demethylase of Candida albicans and Its Interaction with Azole Antifungals
Haitao Ji,
Wannian Zhang,
Youjun Zhou,
Min Zhang,
Jie Zhu,
Yunlong Song,
Jiaguo Lü, and
Jü Zhu
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2506-2513
Docking-Based Development of Purine-like Inhibitors of Cyclin-Dependent Kinase-2
Michal Otyepka,
Vladimír Krytof,
Libor Havlíek,
Vra Siglerová,
Miroslav Strnad, and
Jaroslav Koa
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2514-2522
6-Acyloxy(nor)tropanes: Affinities for Antagonist/Agonist Binding Sites on Transfected and Native Muscarinic Receptors
John W. Daly,
Tara H. Gupta,
William L. Padgett, and
Xue-Feng Pei
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2523-2529
4-(3-Chloro-4-methoxybenzyl)aminophthalazines: Synthesis and Inhibitory Activity toward Phosphodiesterase 5
Nobuhisa Watanabe,
Hideyuki Adachi,
Yasutaka Takase,
Hirofumi Ozaki,
Masayuki Matsukura,
Kazuki Miyazaki,
Keiji Ishibashi,
Hiroki Ishihara,
Kohtarou Kodama,
Mayu Nishino,
Motoharu Kakiki, and
Yasuhiro Kabasawa
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2530-2537
A Novel Approach for a Water-Soluble Long-Acting Insulin Prodrug: Design, Preparation, and Analysis of [(2-Sulfo)-9-fluorenylmethoxycarbonyl]3-insulin
Eytan Gershonov,
Itzhak Goldwaser,
Mati Fridkin, and
Yoram Shechter
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2538-2546
Structure-Activity Relationships of (E)-5-(2-Bromovinyl)uracil and Related Pyrimidine Nucleosides as Antiviral Agents for Herpes Viruses
Yongseok Choi,
Ling Li,
Sue Grill,
Elizabeth Gullen,
Chang Soo Lee,
Giuseppe Gumina,
Eisaku Tsujii,
Yung-Chi Cheng, and
Chung K. Chu
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2547-2556
Aureobasidins: Structure-Activity Relationships for the Inhibition of the Human MDR1 P-Glycoprotein ABC-Transporter
Françoise Tiberghien,
Toru Kurome,
Kazutoh Takesako,
Agnès Didier,
Tom Wenandy, and
Francis Loor
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2557-2565
Synthesis and Immunosuppressive Activity of Novel Prodigiosin Derivatives
Roberto D'Alessio,
Alberto Bargiotti,
Orlando Carlini,
Francesco Colotta,
Mario Ferrari,
Paola Gnocchi,
Annamaria Isetta,
Nicola Mongelli,
Pietro Motta,
Arsenia Rossi,
Mario Rossi,
Marcello Tibolla, and
Ermes Vanotti
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2566-2574
Synthesis and Cytokine Modulation Properties of Pyrrolo[2,3-d]-4-pyrimidone Nucleosides
Guangyi Wang,
Robert C. Tam,
Esmir Gunic,
Jinfa Du,
Josie Bard, and
Bharati Pai
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2575-2585
QSAR Model for Drug Human Oral Bioavailability
Fumitaka Yoshida and
John G. Topliss
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2586-2590
Enkephalin Glycopeptide Analogues Produce Analgesia with Reduced Dependence Liability
Edward J. Bilsky,
Richard D. Egleton,
Scott A. Mitchell,
Michael M. Palian,
Peg Davis,
Jason D. Huber,
Heather Jones,
Henry I. Yamamura,
Jacqueline Janders,
Thomas P. Davis,
Frank Porreca,
Victor J. Hruby, and
Robin Polt
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2591-2600
Poly(N-acryl amino acids): A New Class of Biologically Active Polyanions
Alfonso Bentolila,
Israel Vlodavsky,
Rivka Ishai-Michaeli,
Olga Kovalchuk,
Christine Haloun, and
Abraham J. Domb
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BRIEF ARTICLES
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2601-2607
Novel Nonsubstrate Inhibitors of Human Thymidine Phosphorylase, a Potential Target for Tumor-Dependent Angiogenesis
Federico Focher,
Daniela Ubiali,
Massimo Pregnolato,
Chengxin Zhi,
Joseph Gambino,
George E. Wright, and
Silvio Spadari
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BOOK REVIEWS
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2608-2608
Writing Reaction Mechanisms in Organic Chemistry, Second Edition By Audrey Miller and Philippa H. Solomon. Harcourt Academic Press, New York. 2000. xiv + 471 pp. 19 x 23.5 cm. ISBN 0-12- 496712-4. $48.50.
Patrick M. Woster
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2608-2608
The Organic Chemistry of Enzyme-Catalyzed Reactions By Richard B. Silverman. Academic Press, San Diego, CA. 2000. xvii + 717 pp. ISBN 0-12-643745-9. $89.95.
D. Eric Walters
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